Efficacy and safety of Butantan-DV in participants aged 2-59 years through an extended follow-up: results from a double-blind, randomised, placebo-controlled, phase 3, multicentre trial in Brazil

Nogueira ML, et al. Lancet Infect Dis. 2024 Nov;24(11):1234-1244. doi: 10.1016/S1473-3099(24)00376-1. Epub 2024 Aug 5. PMID: 39116904.

​

A flow cytometry-based assay to measure neutralizing antibodies against SARS-CoV-2 virus. 

Pscheidt VM, de Souza PO, Fazolo T, Modena JLP, Simeoni C, Teixeira D, et al. A flow cytometry-based assay to measure neutralizing antibodies against SARS-CoV-2 virus. Cytometry. 2024; 105(6): 446–457. https://doi.org/10.1002/cyto.a.24838

​

A high CMV-specific T cell response associates with SARS-CoV-2-specific IL-17 T cell production.

Frozza, F.T.B., Fazolo, T., de Souza, P.O. et al. A high CMV-specific T cell response associates with SARS-CoV-2-specific IL-17 T cell production. Med Microbiol Immunol 212, 75–91 (2023). https://doi.org/10.1007/s00430-022-00758-1

​

IL-21 treatment recovers follicular helper T cells and neutralizing antibody production in respiratory syncytial virus infection.

Gassen, R.B., Fazolo, T., Nascimento de Freitas, D., Borges, T.J., Lima, K., Antunes, G.L., Maito, F., Bueno Mendes, D.A., Báfica, A., Rodrigues, L.C., Jr, Stein, R., Duarte de Souza, A.P. and Bonorino, C. (2021), IL-21 treatment recovers follicular helper T cells and neutralizing antibody production in respiratory syncytial virus infection. Immunol. Cell Biol., 99: 309-322. https://doi.org/10.1111/imcb.12418

​

Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses.

T Fazolo, K Lima, JC Fontoura, PO de Souza, G Hilario, R Zorzetto, L Rodrigues Júnior, VM Pscheidt, JCF Neto, AF Haubert, I Gambin, AC Oliveira, RS Mello, MB Balbe e Gutierres, RB Gassen, LD Coimbra, A Borin, RE Marques, ITS Sartor, GO Zavaglia, IR Fernandes, HI Nakaya, FH Varela, MP Bonatto, TJ Borges, SM Callegari-Jacques, MSC da Costa, JA Schwartz, MC Scotta, RT Stein, and C Bonorino.

Nature Communications 2021

https://www.nature.com/articles/s41467-021-27120-y

​

SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies.

K Lima, JC Fontoura, PO de Souza, T Fazolo, G Hilario, R Zorzetto, LC Rodrigues Junior, LD Coimbra, A Borin, K Bispo-dos-Santos, F Granja, RE Marques, GO Zavaglia, IR Fernandes, FH Varela, MP Bonatto, ML Tonini, GM Ikeda do Carmo, WA Ferreira de Almeida, TJ Borges, HI Nakaya, JL Proenca-Modena, SM Callegari-Jacques, MC Scotta, RT Stein, and C Bonorino.

Frontiers in Immunology 2022

https://europepmc.org/article/med/36405692

​

Host expression system modulates recombinant Hsp70 activity through post‐translational modifications. 

MM Rigo, TJ Borges, BJ Lang, A Murshid, D Wolfgeher, SK Calderwood, AW Truman, C Bonorino.

The FEBS journal 2020

https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.15279

​

Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance.

JC Fontoura, C Viezzer, FG dos Santos, RA Ligabue, R Weinlich, RD Puga, D Antonow, P Severino, C Bonorino.

Materials Science and Engineering: C 2020

https://www.sciencedirect.com/science/article/pii/S0928493119305934

​

Vaccination with RSV M209-223 peptide promotes a protective immune response associated with reduced pulmonary inflammation.

T Fazolo, RB Gassen, DN de Freitas, TJ Borges, MM Rigo, RD da Silva, F Maito, A Cunha, DAGB Mendes, A Báfica, JE Vargas, APD de Souza, C Bonorino.

Antiviral Research 2018

https://doi.org/10.1016/j.antiviral.2018.07.007

​

March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity.

TJ Borges, N Murakami, FD Machado, A Murshid, BJ Lang, RL Lopes, LM Bellan, M Uehara, KH Antunes, MJ Pérez-Saéz, G Birrane, P Vianna, JIB Gonçalves, RF Zanin, J Azzi, R Abdi, S Ishido, JS Shin, APD Souza, SK Calderwood, LV Riella, C Bonorino.

Nature Communications 2018

https://doi.org/10.1038/s41467-018-05572-z

​

IL‐21 treatment recovers follicular helper T cells and neutralizing antibody production in respiratory syncytial virus infection.

RB Gassen, T Fazolo, DN Freitas, TJ Borges, K Lima, GL Antunes, F Maito, DAG Bueno Mendes, A Báfica, LC Rodrigues Jr, R Stein, APD de Souza, C Bonorino.

Immunology and Cell Biology 2021

https://onlinelibrary.wiley.com/doi/full/10.1111/imcb.12418

​

GRPR antagonist protects from drug‐induced liver injury by impairing neutrophil chemotaxis and motility.

RS Czepielewski, N Jaeger, PE Marques, MM Antunes, MM Rigo, DM Alvarenga, RV Pereira, RD da Silva, TG Lopes, VD da Silva, BN Porto, GB Menezes, C Bonorino.

European Journal of Immunology 2017

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201646394

​

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.

RS Czepielewski, BN Porto, LB Rizzo, C Bonorino.

PNAS 2011

https://www.pnas.org/doi/abs/10.1073/pnas.1110996109

​

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

Y Zhao, CK Lee, C-H Lin, RB Gassen, X Xu, Z Huang, C Xiao, C Bonorino, L-F Lu, JD Bui, E Hui.

Immunity 2019

https://doi.org/10.1016/j.immuni.2019.11.003